| Abstrakt: |
Ticks' saliva presents immunomodulatory activity and cause several tissue changes at the attachment site on the host skin. Here, we compare different moments of the skin of a Mangalarga Marchador mare before, during and after tick attachment. At the attached site, it was observed inflammatory infiltrate, degranulated mast cells, areas with an absence of nucleus and the presence of pyknotic nuclei, and thick type I collagen bundles around the tick's hypostome, fibrosis, and necrosis. In the skin after the tick detached, we have also observed a complete loss of the structure of the extracellular matrix due to the formation of edema, a large presence of eosinophils and macrophages, new blood vessels, and dilated vessels. These findings indicate that in the absence of immunomodulation promoted by tick saliva, the animal's organism can start the skin repair and wound healing process. [ABSTRACT FROM AUTHOR] |
