| Autor: |
Isnardi, Carolina A., Cerda, Osvaldo L., Landi, Margarita, Cruces, Leonel, Schneeberger, Emilce E., Calle Montoro, Claudia, Alfaro, María Agustina, Roldán, Brian M., Gómez Vara, Andrea B., Giorgis, Pamela, Ezquer, Roberto Alejandro, Crespo Rocha, María G., Reyes Gómez, Camila R., de los Ángeles Correa, Mária, Rosemffet, Marcos G., Carrizo Abarza, Virginia, Catalan Pellet, Santiago, Perandones, Miguel, Reimundes, Cecilia, Longueira, Yesica |
| Zdroj: |
Journal of Rheumatology; Dec2022, Vol. 49 Issue 12, p1385-1389, 5p |
| Abstrakt: |
Objective: The aim of this study was to assess the immune response after a third dose of SARS-CoV-2 vaccine in patients with rheumatoid arthritis (RA) with undetectable antibodies titers after the primary regimen of two doses.Methods: Patients with RA with no seroconversion after two doses of SARS-CoV-2 vaccine, who received a third dose of either mRNA or vector-based vaccines were included. Anti-SARSCoV- 2 IgG antibodies, neutralizing activity and T cell responses were assessed after the third dose.Results: A total of 21 non-responder patients were included. At vaccination time, 28.6% were receiving glucocorticoids, 85.1% b-DMARDs (including 6 abatacept (ABT) and 4 rituximab (RTX)). The majority (95.2%) received BNT162b2 vaccine and only one of them ChAdOx1 nCoV-19. After the third dose, 90.5% of the patients presented detectable anti-SARS-CoV-2 IgG and 76.2% neutralizing activity. Compared to other treatments, ABT and RTX was associated with the absence of neutralizing activity in 4/5 (80%) patients and lower titers of neutralizing antibodies [median 1/3 (IQR 0-1/20) vs 1/8 (IQR 1/4-1/128), p=0.197]. Specific T-cell response was detected in 41.2% of all patients after the second dose, increasing to 71.4% after the third dose. The use of ABT was associated with a lower frequency of T-cell response (33.3% vs 86.7%, p=0.031).Conclusion: In this RA cohort who failed to seroconvert after two doses of SARS-CoV-2 vaccine, 90.5% presented detectable anti-SARS-CoV-2 IgG after a third dose. The use of ABT was associated with a lower frequency of specific T-cell response. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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