Is this a true lambda free light chain?

Autor: Volovik, Yael, Nimri-Ammouri, Suheir, Adler, Tanya, Barak, Mira, Henig, Clara
Předmět:
Zdroj: Clinical Chemistry & Laboratory Medicine; 2023, Vol. 61 Issue 2, pe36-e37, 2p
Abstrakt: Nevertheless, in the remaining four samples (summarized in Table 1) the -FLC band was still present shifted to a new migration point (indicated by a black arrow) that was different from the intact IgM- immunoglobulin band location, on the sIF gel (Figure 1, lanes 7-12). In order to further evaluate this phenomenon we performed additional specific sIF tests on previously typed as IgM- positive routine samples (with total IgM 1.46-49.33 g/L, M. protein<30.8 g/L, -FLC 9.25-1145 mg/L), using a FLC antisera. The quantitative -FLC values determined were far below the minimal detection limit of the immunofixation gel (120 mg/L for the Electrophoresis protein - (ELP) lane and 50 mg/L for the -free lane) [[3]], thus the -FLC band was supposed not to be visible on the sIF. [Extracted from the article]
Databáze: Complementary Index