| Autor: |
Wang, Meng‐Yao, Zhu, Wei‐Wen, Zhang, Jia‐Yi, Yu, Miao, Zhai, Run‐Dong, Liu, Lai‐Kui |
| Předmět: |
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| Zdroj: |
Oral Diseases; Jan2023, Vol. 29 Issue 1, p154-164, 11p, 4 Color Photographs, 1 Diagram, 1 Chart |
| Abstrakt: |
Objective: Tertiary lymphoid structures (TLSs) provide sites for antigen presentation and activation of lymphocytes, promoting their infiltration; thus, enhancing specific immune responses. The aim of this comparative cross‐sectional study was to reveal the characteristics and influence of TLSs in oral lichen planus (OLP) and oral epithelial dysplasia (OED) with lichenoid features. Methods: Clinical information and samples of 51 OLP and 19 OED with lichenoid features were collected. Immunohistochemistry was performed, and the structures where CD20+ B cells and CD3+ T cells aggregated with peripheral lymph node addressin positive (PNAd+) vessels were defined as TLSs. The results and clinical information were analysed. Result: TLS were found in 44 (86.3%) patients with OLP and 19 (100%) patients with OED. The TLS score was higher in OED group (p = 0.023), accompanied by an increased number of PNAd+ vessels. The TLS was significantly correlated with PNAd+ vessels (p = 0.027), CD20+ B (p < 0.001) and CD208+ dendritic cells (p = 0.001). Foxp3+ Treg cells but not CD8+ T cells infiltrated more severely in OED (p = 0.003) and increased when TLS score was high (p = 0.002). Conclusions: This study revealed the widespread development of TLSs in the OLP and OED. The presence of TLSs showed a close relationship with dysplasia and may increase malignant potency by over‐inducing Treg cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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