| Abstrakt: |
Parkinson's Disease (PD) is a neurodegenerative disease that affects 0.1% of the general public, especially older people. Due to this fact, the medical community pays more and more attention to the pathology, risk factors, and treatments of PD. The fundamental pathology of PD includes misfolding and Lewy Bodies, which are cytotoxic and accumulate in different parts of the brain and eventually kill the dopaminergic neurons. The loss of the dopaminergic neurons affects the motor signaling pathway in the brain the most while affecting other pathways in the brain as well. The risk factors of PD could be genetic or environmental, including oxidative stress. According to advanced research nowadays, it seems like PD is the result of combining all the factors, especially aging and environmental ones. Unfortunately, the medical community has not come up with a treatment to heal PD patients, but rather alleviating the symptoms or slowing down the progress. However, the drug Levodopa (L-dopa), though causing certain complications, shows effective results on patients and the surgical treatment for those who are not responsive to drugs anymore. [ABSTRACT FROM AUTHOR] |
