| Autor: |
Park, Chan Hee, Lee, Jeong Woo, Lee, Hak Jae, Oh, Dong Kyu, Park, Mi Hyeon, Lim, Chae-Man, Hong, Suk-Kyung, the Korean Sepsis Alliance (KSA) investigators, Hong, Sang-Bum, Suh, Gee Young, Jeon, Kyeongman, Ko, Ryoung-Eun, Cho, Young-Jae, Lee, Yeon Joo, Lim, Sung Yoon, Park, Sunghoon, Kwak, Sang Hyun, Lee, Song-I., Moon, Jae Young, Kim, Kyung Chan |
| Předmět: |
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| Zdroj: |
BMC Infectious Diseases; 12/19/2022, Vol. 22 Issue 1, p1-11, 11p |
| Abstrakt: |
Background: Sepsis is the most common cause of death in hospitals, and intra-abdominal infection (IAI) accounts for a large portion of the causes of sepsis. We investigated the clinical outcomes and factors influencing mortality of patients with sepsis due to IAI. Methods: This post-hoc analysis of a prospective cohort study included 2126 patients with sepsis who visited 16 tertiary care hospitals in Korea (September 2019–February 2020). The analysis included 219 patients aged > 19 years who were admitted to intensive care units owing to sepsis caused by IAI. Results: The incidence of septic shock was 47% and was significantly higher in the non-survivor group (58.7% vs 42.3%, p = 0.028). The overall 28-day mortality was 28.8%. In multivariable logistic regression, after adjusting for age, sex, Charlson Comorbidity Index, and lactic acid, only coagulation dysfunction (odds ratio: 2.78 [1.47–5.23], p = 0.001) was independently associated, and after adjusting for each risk factor, only simplified acute physiology score III (SAPS 3) (p < 0.001) and continuous renal replacement therapy (CRRT) (p < 0.001) were independently associated with higher 28-day mortality. Conclusions: The SAPS 3 score and acute kidney injury with CRRT were independently associated with increased 28-day mortality. Additional support may be needed in patients with coagulopathy than in those with other organ dysfunctions due to IAI because patients with coagulopathy had worse prognosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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