| Autor: |
Riel, Hayley, Rudolph, Erica, MacPhee, Catrina, Tibbo, Philip G., Fisher, Derek J. |
| Předmět: |
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| Zdroj: |
Neuropsychobiology; 2022, Vol. 81 Issue 6, p506-515, 10p |
| Abstrakt: |
Introduction: The present study compared the mismatch negativity (MMN) and P3a waveforms among early-phase psychosis (EPP; n = 13) individuals and healthy controls (n = 30) to contribute to the research on these waveforms as potential biomarkers for schizophrenia. Methods: MMN and P3a were elicited with a novelty paradigm using complex stimuli with electrophysiological technology. Results: No significant group differences of amplitude were observed with either waveform. Increased asociality and blunted affect were associated with a reduction in both MMN and P3a waveforms indicating a relationship between these negative symptoms and cognitive deficits. Good social and occupational functioning correlated with improved MMN and P3a waveforms in the EPP group. Conclusions: This study suggests that MMN and P3a may be more appropriately used as an indicator of illness progression and symptomology rather than a biomarker in the early phase of the illness. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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