| Autor: |
Tarhini, Ahmad A., Hanayneh, Wissam B., Powers, John J., Segura, Carlos M. Moran, Conejo-Garcia, Jose R., Lam, Cesar A., Hakam, Ardeshir, Hoffman, Mitchel S. |
| Předmět: |
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| Zdroj: |
Frontiers in Oncology; 11/30/2022, Vol. 12, p01-07, 7p |
| Abstrakt: |
Optimal management of locally advanced vaginal mucosal melanoma is poorly understood because of its rarity and unique biology. Patients have a poor prognosis despite aggressive management approaches including pelvic exenteration and adjuvant radiation that carry major morbidities. We report a case of a patient in early 40's who experienced complete pathologic response and organ preservation following immunotherapy consisting of 3 cycles of ipilimumab and nivolumab. Treatment was complicated by a high-grade immune mediated hepatitis that eventually resolved with immunosuppressive therapy. Immune monitoring studies utilizing vaginal tumor biopsies showed evidence of enhanced infiltration by CD3+/CD8+ cytotoxic T-cells and increased expression of MHC-I/PD-L1 within the tumor microenvironment following immunotherapy. The patient continues to be without evidence of disease recurrence by radiologic and gynecologic examinations with more than 2 years of follow up from the time of immunotherapy initiation. To our knowledge, this is the only case report in the literature of a patient with locally advanced vaginal mucosal melanoma experiencing a durable complete pathologic response and organ preservation following immune checkpoint blockade as the only treatment approach. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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