| Autor: |
Kanai, Y., Akatsuka, T., Kubota, T., Goto, S., Stollar, B. D. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Jan1985, Vol. 59 Issue 1, p139-145, 7p |
| Abstrakt: |
MRL/Mp-lpr/lpr (MRL/l) mice spontaneously produce antibodies to poly (ADP-ribose) that are cross-reactive with single stranded DNA (ssDNA). Spleen cells from these animals were used for fusion with murine plasmacytoma cells to prepare hybridomas that produce autoantibodies to poly (ADP-ribose). Monoclonal antibodies (MoAb) produced by the selected hybridomas not only preferred ssDNA to poly (ADP-ribose). hut also reacted with left handed Z-DNA; the MoAb reflected the nature of serum antibodies to poly (ADP-ribose) in MRL/l mice. These results suggest that similar antigenic determinants exist in poly (ADP-ribose). ssDNA and left handed Z-DNA and that the cross-reactive nature of autoantibodies to poly (ADP-ribose) in MRL/1 mice may be the results of expansion of such clones as selected in this experiment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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