| Autor: |
Kaw, Madhukar, Silverman, William B., Kabinovitz, Mordechai, Schade, Robert K. |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Jan1995, Vol. 90 Issue 1, p72-75, 4p, 2 Black and White Photographs, 3 Charts |
| Abstrakt: |
By conventional criteria the diagnosis or primary sclerosing cholangitis (PSC) is excluded if biliary tract calculi are present. Objective: To compare patients with sclerosing cholangitis with and without calculi. Methods: Retrospective review between 8/91 and 9/93 identified 63 patients with sclerosing cholangitis alone (Group A) and 22 patients with sclerosing cholangitis and biliary tract calculi (Group B). The mean follow-up was 13.6 months. Clinical features reviewed were age, sex, associated inflammatory disease (IBD), and clinical presentation. Cholongiographic features compared were site and extent of disease. Endoscopic stone extraction was reviewed for success and complications. Results: Both groups had the following features in common: 1) mean age (45.9 vs 46.3 yr), 2) prevalence of IBD (68.3% vs 72.7%), 3) extent of bile duct strictures (intrahepatic: 28.5% V5 27.2%; extrahepatic: 12.7% vs 13.6%: both: 58.7% r.v 54.5%). There were proportionately more women in Group B (45.5% rv 33.3%). Symptomatic presentation (pain, pruritis, jaundice, and cholangitis) was seen more often in Group B: 86.4% compared with Group A: 39.7% (specifically cholangitis was seen in 22.7% v.v 4.7%). Among Group B. calculi developed subsequent (mean 40.2 months) after the diagnosis of sclerosing cholangitis in 77.3% of patients. The distribution of calculi was cholelithiasis: 7 (31.8%): choledocholithiasis: 9 (40.9%); and both: 6 (27.2%). Of the patients with choledocholitbiasis alone, 78% bad undergone previous cholecystectomy. Endoscopic stone extraction was successful in 13 (86.6%) of the patients with choledocholithiasis. Complications included mild pancreatitis in one patient and bleeding from sphincterotomy site in another patient which responded to sclerotherapy. In follow-up, only one patient had recurrent calculi and underwent successful stone extraction. Conclusion: We suggest that biliary tract calculi are a part of the spectrum... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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