Increased Prevalence of Unstable HLA-C Variants in HIV-1 Rapid-Progressor Patients.

Autor: Stefani, Chiara, Sangalli, Antonella, Locatelli, Elena, Federico, Tania, Malerba, Giovanni, Romanelli, Maria Grazia, Argañaraz, Gustavo Adolfo, Da Silva, Bosco Christiano Maciel, Da Silva, Alberto Jose Duarte, Casseb, Jorge, Argañaraz, Enrique Roberto, Ruggiero, Alessandra, Zipeto, Donato
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Zdroj: International Journal of Molecular Sciences; Dec2022, Vol. 23 Issue 23, p14852, 9p
Abstrakt: HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps, n = 48), long-term non-progressors (LTNPs, n = 37), and elite controllers (ECs, n = 11). HLA-C variants were classified as stable or unstable according to their binding stability to β2-microglobulin/peptide complex. Our results showed a significant correlation between rapid progression to AIDS and the presence of two or one unstable HLA-C variants (p-value: 0.0078, p-value: 0.0143, respectively). These findings strongly suggest a link between unstable HLA-C variants both at genotype and at allele levels and rapid progression to AIDS. This work provides further insights into the impact of host genetic factors on AIDS progression. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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