| Autor: |
Romero Núñez, Eunice, Blanco Ayala, Tonali, Vázquez Cervantes, Gustavo Ignacio, Roldán-Roldán, Gabriel, González Esquivel, Dinora Fabiola, Muñiz-Hernández, Saé, Salazar, Alelí, Méndez Armenta, Maricela, Gómez-Manzo, Saúl, González-Conchillos, Hugo, Luna-Nophal, Angélica, Acosta Ramírez, Alma Patrica, Pineda, Benjamín, Jiménez-Anguiano, Anabel, Pérez de la Cruz, Verónica |
| Předmět: |
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| Zdroj: |
Cells (2073-4409); Dec2022, Vol. 11 Issue 23, p3819, 16p |
| Abstrakt: |
The activation of the maternal immune system by a prenatal infection is considered a risk factor for developing psychiatric disorders in the offspring. Toxoplasma gondii is one of the pathogenic infections associated with schizophrenia. Recent studies have shown an association between high levels of IgG anti-T. gondii from mothers and their neonates, with a higher risk of developing schizophrenia. The absence of the parasite and the levels of IgGs found in the early stages of life suggest a transplacental transfer of the anti-T. gondii IgG antibodies, which could bind fetal brain structures by molecular mimicry and induce alterations in neurodevelopment. This study aimed to determine the maternal pathogenic antibodies formation that led to behavioral impairment on the progeny of rats immunized with T. gondii. Female rats were immunized prior to gestation with T. gondii lysate (3 times/once per week). The anti-T. gondii IgG levels were determined in the serum of pregestational exposed females' previous mating. After this, locomotor activity, cognitive and social tests were performed. Cortical neurotransmitter levels for dopamine and glutamate were evaluated at 60 PND in the progeny of rats immunized before gestation (Pregestational group). The maternal pathogenic antibodies were evidenced by their binding to fetal brain mimotopes in the Pregestational group and the reactivity of the serum containing anti-T. gondii IgG was tested in control fetal brains (non-immunized). These results showed that the Pregestational group presented impairment in short and long-term memory, hypoactivity and alteration in social behavior, which was also associated with a decrease in cortical glutamate and dopamine levels. We also found the IgG antibodies bound to brain mimotopes in fetuses from females immunized with T. gondii, as well as observing a strong reactivity of the serum females immunized for fetal brain structures of fetuses from unimmunized mothers. Our results suggest that the exposure to T. gondii before gestation produced maternal pathogenic antibodies that can recognize fetal brain mimotopes and lead to neurochemical and behavioral alterations in the offspring. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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