Painful Temporomandibular Joint Clicking: A Genetic Point of View.
| Autor: | Lorenzi Poluha, Rodrigo, Carvalho Soares, Flávia Fonseca, D'Aurea Furquim, Bruno, De la Torre Canales, Giancarlo, Sales Pinto Fiamengui, Lívia Maria, Rigoldi Bonjardim, Leonardo, Rodrigues Conti, Paulo César |
|---|---|
| Předmět: |
PILOT projects
INTERLEUKINS STATISTICS TEMPOROMANDIBULAR joint PAIN SINGLE nucleotide polymorphisms ONE-way analysis of variance GENETIC polymorphisms HEALTH outcome assessment MATRIX metalloproteinases PAIN threshold COMPARATIVE studies PEARSON correlation (Statistics) GENOTYPES TUMOR necrosis factors CHI-squared test DESCRIPTIVE statistics RESEARCH funding POLYMERASE chain reaction DATA analysis DATA analysis software |
| Zdroj: | Journal of Oral & Facial Pain & Headache; 2022, Vol. 36 Issue 3/4, p229-235, 7p |
| Abstrakt: | Aims: To determine whether there is an association between gene polymorphisms and patients with painful temporomandibular joint (TMJ) clicking when compared to patients with painless TMJ clicking and a healthy control group. Methods: In this pilot study, the genotypic and allelic frequencies of candidate single-nucleotide polymorphisms (SNP) were compared among 60 individuals divided equally into three groups: patients with painful TMJ clicking (n = 20); patients with painless TMJ clicking (n = 20); and healthy controls (n = 20). Participants were genotyped for the following SNPs using real-time polymerase chain reaction: MMP1 --16071G/2G, COMT Val158Met, TNFα --308, IL1β +3954, IL6 --174, and IL10 --1082. The pressure pain threshold (PPT) of the TMJ was also assessed. All variables were compared among groups. Results: Patients with painful TMJ clicking had a significant association and a higher frequency of MMP1 --16071G/2G (P = .042), COMT Val158Met (P = .030), and TNFα --308 (P = .016) when compared to the other groups, as well as a lower frequency of IL10 --1082. Considering PPT values, a progressively lower mean was found in individuals with painful TMJ clicking, followed sequentially by the painless TMJ clicking and the control groups. Conclusion: This pilot study showed that patients with painful TMJ clicking had a significant association with mutant genotypes related to degradation of extracellular matrix components, pain, proinflammation, and anti-inflammation. Furthermore, these patients also had significantly lower TMJ PPT values in all comparisons. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
| Externí odkaz: |
|