| Autor: |
Kikendall, James Walter, Glass, Allan R., Sobin, Leslie H., Bowen, Phyllis E. |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Oct1992, Vol. 87 Issue 10, p1394-1397, 4p, 1 Chart, 2 Graphs |
| Abstrakt: |
Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinomas (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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