Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes.

Autor:	Abpeikar, Zahra, Milan, Peiman Brouki, Moradi, Lida, Anjomshoa, Maryam, Asadpour, Shiva
Předmět:	ARTICULAR cartilage CARTILAGE cells CARTILAGE regeneration TISSUE scaffolds HEMATOXYLIN & eosin staining TISSUE engineering CARTILAGE HUMAN beings
Zdroj:	Mechanics of Advanced Materials & Structures; 2022, Vol. 29 Issue 26, p4911-4922, 12p
Abstrakt:	Articular cartilage has weak intrinsic self-healing capacity. Tissue engineering is an appropriate option for cartilage regeneration. This research was designed to evaluate the effects of pore size in scaffolds on mechanical properties and chondrocyte-scaffold interactions. PCL scaffolds were fabricated with large, medium, and small pore sizes. The constructs were analyzed by SEM, swelling tests, mechanical tests, MTT assay, and H&E staining after chondrocyte seeding. Mechanical features of the scaffolds were near to human articular cartilage. Our findings suggest that the PCL scaffold with medium pore sizes provides suitable mechanical strength and better chondrocyte-scaffold interactions simultaneously for application in cartilage. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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