NIP domain prevents N-type inactivation in voltage-gated potassium channels.

Autor: Roeper, Jochen, Sewing, Sabine, Zhang, Ying, Sommer, Tobias, Wanner, Siegmund G., Pongs, Olaf
Předmět:
Zdroj: Nature; 1/22/1998, Vol. 391 Issue 6665, p390, 4p, 6 Black and White Photographs, 18 Diagrams
Abstrakt: Presents research which discovered the N-type inactivation-prevention (NIP) domain, which neutralizes the activity of Kv-alpha- and Kv-beta-inactivation gates. Assembly of shaker-related voltage-gated K+ (Kv) channels; Formation of highly diverse heteromultimeric Kv channels; Principal inactivation mechanisms; Assembly of heteromultimers; Gating phenotype of heteromultimers; Mediation by heteromultimers; More.
Databáze: Complementary Index