| Abstrakt: |
In a drug delivery system, a piezoelectric micropump plays a vital role to deliver precise volume and concentration of the drug. Micropump in the modern infusion system should vary the flow rate of the drug according to prescribed infusion volume and profile. However, piezo actuated micropumps create intermittent flow due to flow pulsations. In this paper, a novel digital offset switching (DOS) strategy was proposed to develop desired uniform flow, minimize flow pulsations and reduce medication error. The proposed strategy was implemented on the developed digital multiple micropump infusion system (DMMIS). The unique configuration of DMMIS contains a parallel arrangement of piezoelectric micropumps with associated drivers, controller, sensors, and instrumentation. The flow capacity of multiple piezoelectric micropumps was sized with binary and Fibonacci sequence based sizing techniques. Comprehensive experimental studies were conducted to analyse the effectiveness of the proposed switching strategy when compared to existing parallel switching and sequential switching strategies. Wherein, three dosing cycles were formulated to study the effect of switching strategies on flow characteristics. The optimal dosing cycle was selected based on the mean absolute percentage error (MAPE), degree of flow pulsation (DFP), and absolute medication error percentage (AMEP). The results show that the binary dosing cycle with the DOS strategy was the optimal dosing cycle with 7.51% MAPE, 5.14% DFP, and 4.6% AMEP. The experimental studies have reported that the DOS strategy has effectively minimized the MAPE, DFP, and AMEP in dosing cycles. [ABSTRACT FROM AUTHOR] |
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