| Autor: |
Taso, Manuel, Munsch, Fanny, Girard, Olivier M., Duhamel, Guillaume, Alsop, David C., Varma, Gopal |
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| Zdroj: |
Magnetic Resonance in Medicine; Feb2023, Vol. 89 Issue 2, p550-564, 15p |
| Abstrakt: |
Purpose: To evaluate the benefits of fast spin echo (FSE) imaging over rapid gradient‐echo (RAGE) for magnetization‐prepared inhomogeneous magnetization transfer (ihMT) imaging. Methods: A 3D FSE sequence was modified to include an ihMT preparation (ihMT‐FSE) with an optional CSF suppression based on an inversion‐recovery (ihMT‐FLAIR). After numeric simulations assessing SNR benefits of FSE and the potential impact of an additional inversion‐recovery, ihMT‐RAGE, ihMT‐FSE, and ihMT‐FLAIR sequences were compared in a group of six healthy volunteers, evaluating image quality, thermal, and physiological noise as well as quantification using an ihMT saturation (ihMTsat) approach. A preliminary exploration in the cervical spinal cord was also conducted in a group of three healthy volunteers. Results: Several fold improvements in thermal SNR were observed with ihMT‐FSE in agreement with numerical simulations. However, we observed significantly higher physiological noise in ihMT‐FSE compared to ihMT‐RAGE that was mitigated in ihMT‐FLAIR, which provided the best total SNR (+74% and +49% compared to ihMT‐RAGE in the white and gray matter, P ≤ 0.004). IhMTsat quantification was successful in all cases with strong correlation between all sequences (r2 > 0.75). Early experiments showed potential for spinal cord imaging. Conclusions: FSE generally offers higher SNR compared to gradient‐echo based acquisitions for magnetization‐prepared contrasts as illustrated here in the case of ihMT. However, physiological noise has a significant effect, but an inversion–recovery‐based CSF suppression was shown to be efficient in mitigating effects of CSF motion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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