Sesquiterpenoids from Ixeris sonchifolia and their neuroprotective activities.

Autor:	Yuan, Yan, Hu, Zhuo-Fan, Wang, Feng-Li, Wan, Luo-Sheng, Gong, Ying, Chen, Jia-Chun
Předmět:	HYDROCARBON analysis EXPERIMENTAL design HIGH performance liquid chromatography NUCLEAR magnetic resonance spectroscopy PHYTOCHEMICALS NEUROPROTECTIVE agents MASS spectrometry TOXICITY testing DESCRIPTIVE statistics RESEARCH funding PLANT extracts MOLECULAR structure INFRARED spectroscopy CHINESE medicine PHARMACODYNAMICS
Zdroj:	Journal of Asian Natural Products Research; Nov2022, Vol. 24 Issue 11, p1071-1077, 7p
Abstrakt:	The phytochemical investigation of the methanol extract of Ixeris sonchifolia led to the isolation and identification of nine analogs, including one new guaiane-type sesquiterpenoid, named ixerinoid A (1). The structure of 1 was determined by extensive analysis of the 1 D and 2 D nuclear magnetic resonance spectroscopic data, as well as quantum chemical calculations. Additionally, all the isolates were tested for their neuroprotective activity using the oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cell injury model. Compounds 3, 5, 6, 8, and 9 displayed remarkable protective effects at concentrations of 1, 5, and 10 μM, respectively. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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