| Autor: |
Frazzini, Valerio, Whitmarsh, Stephen, Lehongre, Katia, Yger, Pierre, Lemarechal, Jean-Didier, Mathon, Bertrand, Adam, Claude, Hasboun, Dominique, Lambrecq, Virginie, Navarro, Vincent |
| Předmět: |
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| Zdroj: |
Frontiers in Neurology; 11/11/2022, Vol. 13, p1-15, 15p |
| Abstrakt: |
Periventricular nodular heterotopia (PNH) is a malformation of cortical development that frequently causes drug-resistant epilepsy. The epileptogenicity of ectopic neurons in PNH as well as their role in generating interictal and ictal activity is still a matter of debate. We report the first in vivo microelectrode recording of heterotopic neurons in humans. Highly consistent interictal patterns (IPs) were identified within the nodules: (1) Periodic Discharges PLUS Fast activity (PD+F), (2) Sporadic discharges PLUS Fast activity (SD+F), and (3) epileptic spikes (ES). Neuronal firing rates were significantly modulated during all IPs, suggesting that multiple IPs were generated by the same local neuronal populations. Furthermore, firing rates closely followed IP morphologies. Among the different IPs, the SD+F pattern was found only in the three nodules that were actively involved in seizure generation but was never observed in the nodule that did not take part in ictal discharges. On the contrary, PD+F and ES were identified in all nodules. Units that were modulated during the IPs were also found to participate in seizures, increasing their firing rate at seizure onset and maintaining an elevated rate during the seizures. Together, nodules in PNH are highly epileptogenic and show several IPs that provide promising pathognomonic signatures of PNH. Furthermore, our results show that PNH nodules may well initiate seizures. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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