| Autor: |
de Oliveira Micheletti, Thayana, Cassia dos Santos, Andressa, Zweig Rocha, Guilherme, Silva, Vagner Ramon Rodrigues, Quaresma, Paula Gabriele Fernandes, Balan Assalin, Heloisa, Silva Junqueira, Felipe, Rochete Ropelle, Eduardo, Gabarra Oliveira, Alexandre, Abdalla Saad, Mario Jose, de Oliveira Prada, Patricia |
| Předmět: |
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| Zdroj: |
Frontiers in Physiology; 11/14/2022, Vol. 13, p1-16, 16p |
| Abstrakt: |
Background: Acute exercise contributes to decreased feeding through leptin and interleukin/Janus kinase 2/signal transducers and activators of transcription 3 (IL-6/JAK2/STAT3) signaling. Considering the pleiotropic use of substrates by JAK2 and that JAK2 can phosphorylate the Tubby protein (TUB) in CHO-IR cells, we speculated that acute exercise can activate the IL-6/JAK2/TUB pathway to decrease food intake. Aims: We investigated whether acute exercise induced tyrosine phosphorylation and the association of TUB and JAK2 in the hypothalamus and if IL-6 is involved in this response, whether acute exercise increases the IL- 6/TUB axis to regulate feeding, and if leptin has an additive effect over this mechanism. Methods: We applied a combination of genetic, pharmacological, and molecular approaches. Key findings: The in vivo experiments showed that acute exercise increased the tyrosine phosphorylation and association of JAK2/TUB in the hypothalamus, which reduced feeding. This response was dependent on IL-6. Leptin had no additive effect on this mechanism. Significance: The results of this study suggest a novel hypothalamic pathway by which IL-6 released by exercise regulates feeding and reinforces the beneficial effects of exercise. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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