| Autor: |
Nguyen, Gia-Nam, Jordan, Erin Noel, Kayser, Oliver |
| Předmět: |
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| Zdroj: |
Synthesis; Dec2022, Vol. 54 Issue 24, p5540-5550, 11p |
| Abstrakt: |
An efficient synthesis of 2,5-dihydrobenzoxepine analogues was developed without using protecting groups. Regioselective allylation was optimized through a recent method utilizing magnesium dicarboxylates. Grubbs catalysts were applied to investigate ring-closing metathesis. The scope of the present route was extended to produce four analogues, which provided novel cannabinoid-like 2,5-dihydrobenzoxepines in sufficient quantities to permit in vitro assays on recombinant CB1/CB2 receptors. In vitro assays related to CB1/CB2 receptors did not indicate any activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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