| Autor: |
Mondal, Pinku Prasad, Pal, Amit, Prakash, Athira K, Sahoo, Basudev |
| Předmět: |
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| Zdroj: |
Chemical Communications; 12/11/2022, Vol. 58 Issue 95, p13202-13205, 4p |
| Abstrakt: |
A silver-catalysed oxidative sp2 C–H alkylation of N-heteroarenes with ketone-derived 2,3-dihydroquinazolinones at room temperature is developed. The combination of a metal catalyst and perdisulfate oxidant promotes the rarely explored thermal activation of pre-aromatic 2,3-dihydroquinazolinone to generate an alkyl radical, supported by mechanistic studies. In addition to the broad scope, good functionality tolerance, late stage functionalization of APIs, and synthesis of a novel Papaverine analogue, the utilization of an N-heteroarene C–H bond and ketone as a non-trivial alkyl radical source represents the salient feature of this method. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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