| Autor: |
Lu, Yuanqing, Wang, Liqun R., Lee, Jungnam, Mohammad, Naweed S., Aranyos, Alek M., Gould, Calvin, Khodayari, Nazli, Oshins, Regina A., Moneypenny, Craig G., Brantly, Mark L. |
| Předmět: |
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| Zdroj: |
Hepatology Communications; Dec2022, Vol. 6 Issue 12, p3599-3599, 1p |
| Abstrakt: |
We are aware of the age-related changes in the number of Z alpha-1 antitrypsin globules found in the liver of murine models of alpha-1 antitrypsin deficiency, and as such, we studied mice only between the ages of 6 and 12 months. This observation leads us to believe that decreases in globules are caused by cellular adaptation to Z alpha-1 antitrypsin disposal rather than down-regulation of alpha-1 antitrypsin gene expression. In our murine models, we have noted a decrease in Z alpha-1 antitrypsin globules while the alpha-1 antitrypsin levels in plasma remain constant as the mice age. [Extracted from the article] |
| Databáze: |
Complementary Index |
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