| Autor: |
Morali, Gilles A., Braverman, Dan Z., Lissi, Joseph, Goldstein, Robert, Jacobsohn, Warren Z. |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Aug1991, Vol. 86 Issue 8, p995-999, 5p, 2 Charts, 1 Graph |
| Abstrakt: |
Cholelithiasis is more prevalent in diabetics than in nondiabetics. Gallbladder dysmotility is supposed to be one of the causative factors. Reduced α-adrenergic tone has been demonstrated in the enterocytes of diabetic rats, and its correction by clonidine might explain the beneficial effect that the drug has on diabetic diarrhea. We therefore surmised that diabetic cholecystoparesis could also be due to α-adrenergic alterations. To test this hypothesis, we studied gallbladder contractions by real time ultrasonography, and small bowel transit time by lactulose hydrogen breath test, in 13 insulin-requiring diabetics before and after administration of the α-adrenergic stimulant clonidine (0.3 mg orally). That plasma levels were sufficient was evidenced indirectly by a fall in blood pressure. Clonidine significantly improved the rate of emptying (0.0193 ± 0.00057/min vs. 0.0318 ± 0.0027/min; p < 0.005), but not the fasting and residual gallbladder volumes. Small bowel transit time was significantly prolonged after clonidine (169 ± 17 min vs. 208 ± \1\ p < 0.05). These results suggest that I) reduced α-adrenergic tone corrected by clonidine may be present in the diabetic gallbladder, and 2) clonidine's antidiarrheal effect might be explained, at least in part, by a prolongation of the small bowel transit time. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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