The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis.

Autor: AbdelMassih, Antoine, Agha, Hala, El-Saiedi, Sonia, El-Sisi, Amal, El Shershaby, Meryam, Gaber, Hanya, Ismail, Habiba-Allah, El-Husseiny, Nadine, Amin, Abeer Reda, ElBoraie, Aly, Ayad, Aya, Menshawey, Esraa, Sefein, Fady, Osman, Ibrahim Ihab, Moursi, Mai, Hanafy, Maram, Abdelaziz, Mariam Sherif, Arsanyous, Mariem Badr, Khaled-Ibn-El-Walid, Mariam, Tawfik, Marwa Gamal
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Zdroj: Bulletin of the National Research Centre; 11/17/2022, Vol. 46 Issue 1, p1-8, 8p
Abstrakt: Background: Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others. Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis. Short conclusion: In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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