| Autor: |
Priya, Sathya, Padma, V., Rahul, Thomson, Shiny, Devi, Kannan Meera |
| Předmět: |
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| Zdroj: |
Journal of Pharmaceutical Negative Results; 2022 Special Issue, Vol. 13, p1606-1609, 4p |
| Abstrakt: |
Background: Binswangers disease is a progressive neurological disease caused by atherosclerosis and thrombo-embolism affecting the white matter and blood vessels affecting the deep brain structures (basal ganglia and thalamus). Depending on the vascular etiology, the symptoms and physical effects as-sociated with Binswanger stroke may suddenly worsen, stabilize, and then improve briefly, but the patient's general condition continues to improve as they continue to enter contact with the occluded vessel. High blood pressure, smoking, high cholesterol, heart disease, and diabetes are risk factors for Binswanger's disease. Rare genetic disorders such as autosomal dominant cerebral artery disease (CADASIL) and subcortical infarct and leukoencephalopathy also cause Binswagger disease. Diag-nosing Binswangers disease necessitates using a multimodal approach. More specific tests will be-come accessible in the coming years when novel pathophysiological mechanisms are revealed. It is a complex syndrome caused by variety of factors rather than a single disease. Methods: Seventy years old male presented with complaints of inability to walk, dysarthria, dysphagia, abulia and apathy. He was a known case of systemic hypertension, CAD and Parkinsonism on treatment little supportive for the diagnosis of Binswangers disease. Results: This case describes a clinical approach to Binswangers disease with the finding helpful in consistent with MRI brain findings, CSF flow study and new novel biomarker. Conclusion: A Rare disease with nil significant approach still but a new biomarker is available to come into a conclusion of Binswangers disease. Further investigations will become available in the years to come in order to better treat these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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