| Autor: |
Motoki Ohta, Shigeki Koshida, Itsuki Jimbo, Machi Oda, Ryo Inoue, Takamitsu Tsukahara, Masaki Terahara, Yoshitaka Nakamura, Yoshihiro Maruo |
| Zdroj: |
Pediatrics International; Jan2022, Vol. 64 Issue 1, p1-5, 5p |
| Abstrakt: |
Background: Exosomes are nanosized extracellular vesicles, that play important roles in intercellular immune regulation. They have potential therapeutic utility for neonatal diseases including necrotizing enterocolitis. Breast-milk-derived exosomes have recently shown beneficial effects on intestinal damage in vitro and in vivo. However, the chronological change in breast-milk-derived exosome concentrations after delivery are unclear. Methods: In this prospective study, we enrolled 17 mothers who delivered premature infants admitted to a neonatal intensive care unit in Japan. We measured the consecutive concentrations of breast-milk-derived exosomes in the mothers for 48 weeks after delivery. Results: The median concentration of breast-milk-derived exosomes was 1.62 × 108 particles/ml in colostrum, showing a significant decrease after 2 weeks (P < 0.01). There was no association between the exosome concentration in colostrum and maternal perinatal factors including parity, mode of delivery, maternal age, and gestational age at delivery. Conclusions: We concluded that breast-milk-derived exosomes were the richest in colostrum. Our basic data regarding breast-milk-derived exosomes are expected to aid in the clinical application of exosomes for treating neonatal diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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