Cytoprotective Polyketides from Sponge-Derived Fungus Lopadostoma pouzarii.

Autor:	Trinh, Phan Thi Hoai, Yurchenko, Anton N., Khmel, Olga O., Dieu, Trang Vo Thi, Ngoc, Ngo Thi Duy, Girich, Elena V., Menshov, Alexander S., Kim, Natalya Y., Chingizova, Ekaterina A., Van, Tran Thi Thanh, Lee, Jong Seok, Lee, Hyi-Seung, Yurchenko, Ekaterina A.
Předmět:	POLYKETIDES MARINE fungi ROTENONE FUNGI CANCER cells PROSTATE cancer
Zdroj:	Molecules; Nov2022, Vol. 27 Issue 21, p7650, 12p
Abstrakt:	The new polyketides lopouzanones A and B, as well as the new 1-O-acetyl and 2-O-acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus Lopadostoma pouzarii strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (–)-5-methylmellein, and dendrodochol B, were identified. The structures of the isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of the lopouzanones A and B were determined using the Mosher's method. The cytotoxicity of the isolated compounds against human prostate cancer cells PC-3 and normal rat cardiomyocytes H9c2 was investigated. Gliorosein showed weak DPPH radical-scavenging activity and in vitro cardioprotective effects toward rotenone toxicity and CoCl2-mimic hypoxia. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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