| Autor: |
Yulong, Xia, Fangfang, Fan, Ya, Huo, Yaping, Wei, Meiqing, Huang, Yan, Zhang, Jianping, Li, Lishun, Liu, Jing, Zhou, Yong, Huo |
| Zdroj: |
Journal of Clinical Hypertension; Nov2022, Vol. 24 Issue 11, p1473-1481, 9p |
| Abstrakt: |
The aim of this study was to investigate the association between baseline resting heart rate (RHR) and all‐cause death in the China Stroke Primary Prevention Trial (CSPPT). A post hoc analysis was conducted using data from 20,648 hypertensive adults without cardiovascular disease in the CSPPT and with baseline RHR data available. Over a median follow‐up duration of 4.5 years, the baseline RHR and risk for all‐cause death had a nonlinear relationship. The risk of all‐cause death was higher in participants with an RHR ≥85 bpm (hazard ratio 1.42; 95% confidence interval 1.03–1.96, p =.031) than in those with a baseline RHR of 75–80 bpm. The effect of RHR on all‐cause death during the treatment period was modified by the folate level (p =.020) and systolic blood pressure (SBP) during treatment(p =.056). The effect of RHR on the risk of all‐cause death was stronger when the folate level was low than when it was high; the risk was higher when the RHR was < 75 bpm or ≥80 bpm than when it was 75–80 bpm. RHR had a greater effect on the risk of all‐cause death when SBP during treatment was well controlled than when it was not; again, the risk was higher when the RHR was < 75 bpm or ≥80 bpm than when it was 75–80 bpm. A higher baseline RHR resulted in an increased risk of all‐cause mortality in Chinese adults with hypertension but no history of stroke or myocardial infarction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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