| Autor: |
Calabr&oagrave;, Antonio, Orsini, Barbara, Brocchi, Alessandro, Falchini, Massimo, Fedi, Paolo, Surrenti, Calogero |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Apr1990, Vol. 85 Issue 4, p404-407, 4p, 1 Chart, 1 Graph |
| Abstrakt: |
Immunoreactive epidermal growth factor (TR-EGF) was measured by a highly sensitive and specific radio-immunoassay in gastric juice samples obtained during endoscopy from 26 control subjects, 44 patients with duodenal ulcers, and 18 with benign gastric ulcers. In the active stage, the concentrations of the peptide were consistently reduced, compared with those found in control subjects (592.7 ± 55.8 pg/ml), in both duodenal (262.6 ± 21.4 pg/ml) and gastric ulcer patients (320.2 ± 34.1 pg/ml) (p < 0.001 and 0.01, respectively). Mean IR-EGF values distinctly lower than in the controls were still present in the gastric juice of patients with inactive duodenal ulcers (349.7 ± 35.9 pg/ml; p < 0.001), whereas no difference was observed in patients with healed gastric ulcers (502.2 ± 132.3 pg/ml). Although these findings suggest a possible role for EGF deficiency in the pathogenesis of peptic ulcer disease, the pathophysiological significance of our results (if any) remains to be elucidated. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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