| Autor: |
Haruta, Jun-ichi, Kusugami, Kazuo, Kuroiwa, Atsuo, Ina, Kenji, Shinoda, Masataka, Morise, Kimitomo, Iokawa, Hitoshi, Morita, Mayumi, Ishihara, Akira, Sarai, Susumu |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Apr1992, Vol. 87 Issue 4, p448-454, 7p, 1 Chart, 5 Graphs |
| Abstrakt: |
Phenotypic and functional analysis was performed with lamina propria mononuclear cells (LPMCs) isolated from colonoscopic biopsies in 27 patients with ulcerative colitis (UC). The proportion of T lymphocytes displaying HLA-DR antigens, interleukin 2 (IL-2) receptor, and transferrin receptor was greater in active UC than in control diseases. When LPMCs were cultured with IL-2 or phytohemagglutinin for 72 h, there were no significant differences in the proportion of cells bearing these activation markers between active UC and controls. The proportion of CD56+ cells and lymphokine-activated killer (LAK) cell activity was lower in LPMCs from active UC than in control cells, and depletion of CD56+ cells from control lamina propria cells essentially eliminated LAK cell activity. Mucosal T lymphocytes may be activated in vivo during active inflammation in UC, and lower levels of intestinal LAK cell activity may be related to the decrease of CD56+ cells under these conditions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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