| Autor: |
Andrews, F. M., Riggs, L. M., Lopez, M. J., Keowen, M. L., Garza, F., Takawira, C., Liu, C.‐C., Liu, Y., Seeram, N. P., Cairy, A., St. Blanc, M. |
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| Zdroj: |
Equine Veterinary Education; Dec2022, Vol. 34 Issue 12, pe591-e602, 12p |
| Abstrakt: |
Summary: Background: Herbal supplements containing curcumin and other ingredients are used for pain management in horses with osteoarthritis (OA). Objectives: To test the effects of a herbal supplement containing curcumin and other ingredients in horses with lameness due to naturally occurring OA. Study design: Two‐period randomised crossover design. Methods: Ten Thoroughbreds with naturally occurring chronic OA were randomly assigned to the treatment (BLP; Buteless® Performance) or control (CTR, no supplement) groups and fed daily for 30 days. On Days −1 (before treatment), 15 and 30, lameness examination, range of motion, pain on palpation and force platform data were collected. Plasma curcumin concentration and its metabolites were measured on Days 1 and 14. Gastroscopy, a complete blood count and a serum biochemistry panel were performed on each horse before treatment Day −1 and Day 31. Gastric lesions (ulcers) were scored in real time by a masked investigator. Results: Mean peak vertical force (PVF), measured by the force platform, significantly increased in the lame limb of the BLP‐treated horses on Days 15 (0.40 ± 0.13 N/kg, (p = 0.0025) and 30 (0.63 ± 0.14 N/kg, p < 0.0001) compared to the CTR group. In addition, mean normalised PVF was higher in the BLP group on Day 15 (p = 0.0438) and on day 30 (p = 0.0003) when compared to CTR horses for the same days. The PVF significantly improved (≥5%; range, 5.2–33%) in six of nine individual BLP‐treated horses and did not improve (<5%; range, 0–3.4%) in three of nine BLP‐treated horses. Also, PVF improved (≥5%; range, 7.6–15.4%) in three of nine horses in the CRT group. Squamous gastric lesion scores significantly decreased in both groups by Day 31. Plasma curcumin‐O‐sulphate concentrations (1.2–3.3 ng/ml) were present in 9/10 BLP‐treated horses by Day 14. Main limitations: Small sample size and absence of a positive treatment (non‐steroidal anti‐inflammatory drug) control. Conclusions: The BLP supplement containing curcumin achieved plasma concentrations and improved weight bearing in some treated horses with naturally occurring OA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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