| Autor: |
Maarisit, Wilmar, Untu, Sonny D., Lengkey, Yessie K., Mongi, Jeane, Kanter, Jabes W., Pareta, Douglas N., Sambou, Chistel N., Tumbel, Silvana L., Montolalu, Friska M., Korua, Sandra A., Tulungen, Franky R. |
| Předmět: |
|
| Zdroj: |
Tropical Journal of Natural Product Research; Oct2022, Vol. 6 Issue 10, p1622-1625, 4p |
| Abstrakt: |
Marine invertebrate sponges are a rich source of new bioactive substances. The objective of this investigation was to isolate the anti-mycobacterium bioactive compounds from sponge Haliclona sp. A new alkaloid (1) was obtained through bioassay-guided purification together with eight previously known substances, including cyclostellettamines A (5), B (6), C (7), E (8), and F (9) and the haliclocyclamines A (2), B (3), and C. The structures of 1-9 were established applying spectroscopic analysis, including 1D NMR (1H and 13C-NMR), 2D NMR (HMQC, HMBC, 1H-1H COSY), mass spectroscopy, IR, and UV. Furthermore, the findings revealed that the compounds exhibited inhibitory activity against Mycobacterium smegmatis at 10 µg/disc. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
