| Autor: |
Salman, Noor S., AL-Sharqi, Sahar A. H., Joda, Ali E. |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Oct2022, Vol. 22 Issue 2, p3627-3634, 8p |
| Abstrakt: |
Acute Appendicitis (AA) is one of the most common acute abdominal conditions, which necessitates its appendectomy. This study focuses on evaluating the role of mast cells and some immune factors in the pathogenicity of acute appendicitis in children with AA compared to healthy children. Tissue samples were taken from 30 children with AA (19 males and 11 females) during the appendectomy, and the samples were preserved in 10% formalin for tissue preparation. Blood samples were obtained from 30 AA children and 20 healthy children. These samples were collected from the Central Teaching Hospital for Children in Baghdad during the period from October 2020 to January 2021. The age distribution showed no significant difference between AA patients and the control group. The enumeration of mast cells in the appendix tissue with AA showed an increase in numbers in appendix tissue using Alcian blue safranin, the most predominant grade was grade +1 and +2 more than grade +3 in the AA patients. Some Complete Blood Count (CBC) revealed that there was a significant elevation (p £ 0.01) in the count of total White Blood Cell (WBC), neutrophils and (p £ 0.05) in the count of platelets in the AA patients group compared to the control group. There was non-significant in the count of lymphocyte, Red Blood Cell (RBC) and Hematocrit (HCT) (p < 0.05) in the AA patient groups compared to the control group. There was a highly significant elevation (p < 0.01) in the serum hs-CRP level in the AA group compared to the control group. In conclusion, the study revealed changes in numbers of mast cells and some immune factors results different in AA children compared to healthy children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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