| Autor: |
Mouhsen, Mohammed H., Shabeeb, Zeyad A., Ibraheem, Shaima R. |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Apr2022, Vol. 22 Issue 1, p3341-3347, 7p |
| Abstrakt: |
Immune thrombocytopenia (ITP) is an autoimmune blood disease characterized by a severe decrease in the number of platelets as a result of their destruction by autoantibodies. Patients may present in critical situations, as well as cutaneous and/or mucosal hemorrhages and possibly life-threatening organ hemorrhages. An imbalance between the production of reactive oxygen species (ROS) and the antioxidant defenses that protect cells may give rise to a variety of autoimmune diseases such as ITP. FcγR2a are proteins found on the immune cell surface that bind to IgG and have an important role in immunity; variations in these genes has been implicated in autoimmune disease. The ROS level were investigated in 50 patients with ITP and 30 healthy-looking control using ELISA technique and HRM PCR technology, respectively. The ROS show a high significant difference between the group (P-value = 0.0001) for each Age, Gender, BMI (Kg/m²) and Platelet count (x109/L) and FCγR2A detected in ITP patients while not detected in healthy looking control. The significant increase in ROS level in patients with chronic ITP causes significant oxidative damage resulting from these to most cells and this indicates a role for ROS in autoimmunity and the pathogenesis of chronic ITP. As for the FCγR2A gene, the mutations were found in the gene, with a percentage indicating a molecular biology association with ITP patients among mutant, hetero and wild type. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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