| Autor: |
Ridha, Israa Abdulhussein, Khalaf, Ban Hoshi, Mahdi, Jabbar Fadeel |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Apr2022, Vol. 22 Issue 1, p3183-3187, 5p |
| Abstrakt: |
Metformin is the most widely prescribed oral antidiabetic medication for type 2 diabetes mellitus but its response varies widely between individuals due to the genetic polymorphism in genes that associated with its transportation or with its action.rs2943641 of insulin receptor substrate -1(IRS-1) is one of the polymorphisms that may affect metformin action. This study was performed to study the influence of SNP rs2943641 on metformin response in males with type 2 diabetes mellitus. A cross-sectional study that included 200 patients with type 2 diabetes mellitus was chosen while seeking medical care in an outpatient clinic. A blood sample was drawn from each patient (after signing written consent) for genetic and biochemical parameters analysis. The results revealed that the presence of the C allele of rs2943641 affects metformin response in which patients with CC allele of rs2943641 show decreased response to metformin as compared with patients who had TT and TC alleles. In conclusion, genetic polymorphism of IRS-1 rs2943641have impact on metformin response in patients with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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