| Autor: |
Rwayyih, Hayder S., Khaleel, Luma Waleed |
| Předmět: |
|
| Zdroj: |
Biochemical & Cellular Archives; Apr2022, Vol. 22 Issue 1, p1889-1894, 6p |
| Abstrakt: |
The present experiment was designed to study the protective role of allicin on pathophysiology of heart and aorta in intact and ovariectomized rabbits. A total of forty-two female rabbits (7-8 weeks) have been used in this study. Ovariectomy was performed to twenty eight of female rabbits. The animals were divided equally in to four groups as follows: Group one (GO1): Ovariectomized rabbits received distilled water. Group two (GO2): Ovariectomized rabbits received Allicin orally (10 mg/kg B.wt). Group three (GO3): Ovariectomized rabbits received KCl orally (1.39g Bw). Group four (GO4): Ovariectomized rabbits received Kcl orally (1.39g Bw) and Allicin orally (10 mg/kg B.wt). The histological sections of the heart from the supplemented groups show no clear lesions with normal spindle shape cardiac muscle and intercalated disc with normal aorta and epithelial cells. From the other hand, the ovariectomized rabbits show clear lesions in their heart and aorta. There was clear necrosis of cardiac muscle fibers with fatty dispassion, irregular myocardial endothelial degeneration and congested blood vessels. The aorta of these groups has enlargement and thickening of endothelial cells with infiltration of fatty cells in tunica intima. In conclusions, the result of the current study could prove that Allicin has a protection on cardiovascular system in both intact and ovariectomized female. Allicin could complete the deleterious effect of menopause estrogen deficiency. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
