| Abstrakt: |
The rates of urinary tract infection with multidrug-resistant (MDR) Escherichia coli have dramatically increased and the treatment of these infections with antimicrobial agents (b-lactams, fluoroquinolones, trimethoprim-sulfamethoxazole, nitrofurantoin, etc.) are becoming limited or ineffective due to the increasing frequency of antibiotic-resistant bacteria. The present study aimed to evaluate Fosfomycin pharmacodynamics; the elected E. coli O157:H7 isolate had been subjected to antibiotic susceptibility test, minimum inhibitory concentration (MIC), Minimum bactericidal concentration (MBC) by utilizing of Time kill curve, Post antibiotic effect (PAE) and Mutant prevention concentration (MPC), the results showed that the E. coli O157:H7 isolate was found to be multidrug-resistant (MDR), the MIC value of Fosfomycin against E. coli O157:H7 was 2000 µg/ml, the values of MBC and MPC were 4000 µg/ml for each of them. Furthermore, time-kill analysis demonstrated that Fosfomycin exhibited the highest bactericidal effects of fosfomycin against E. coli O157:H7 was achieved after 4 hrs of posttreatment and lasted up to 24 hrs, while the post-antibiotic effect of Fosfomycin against E. coli O157: H7 was remaining for 72 min. Therefore, we report here that the Fosfomycin was strong enough to overcome of bacterial resistance to these antibiotics and has been suggested as an effective alternative and a promising antimicrobial agent for restoring the efficacy of many antibiotics against MDR E. coli O157:H7. [ABSTRACT FROM AUTHOR] |
