| Abstrakt: |
Diabetes Mellitus (DM) is a chronic metabolic disorder considered by high serum glucose concentration. Type 2 diabetes mellitus (T2DM) be about over 90% of diabetes incidents. CH3L1P has been identified as a marker for infection and endothelial dysfunction. This study is intended to display the effect of duration of T2DM on CH3L1P levels in Iraqi patients with T2DM. Our study consists of 66 patient individuals separated into two groups according to the duration of diabetes, each group consisting of 33 subjects, less than 5 years duration (G1), more than 5 years duration (G2). After overnight fasting were taken approximately 10 ml of venous blood of a participant. The sample was separated into several portions to collect serum for clinical parameter measurement, the anthropometric data record on the same day of sampling, and the CH3L1P level estimated by using an ELISA kit. Our results appeared statistically significant increase different among study groups of BMI, WHR, SBP, DBP, FPG, HbA1c, Insulin, HOMA-IR, Triglyceride, LDL, serum creatinine, blood urea, microalbumin, ACR, CCR, Egfr and CH3L1P at (P<0.001) and Height, HDL, serum albumin, urine creatinine and CRP all showed no significant differences. Results appeared that CH3L1P has a positive significant correlation with hip, duration, Cholesterol, serum creatinine, insulin, HOMAIR, and ACR, while a negative significant correlation was shown with Egfr. Our study concluded that the new inflammatory biomarker chitinase 3-like 1 protein is an extremely sensitive marker as the detector of type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR] |
