Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study.

Autor: Hua, Nadia, Corsten, Martin, Bello, Alexander, Bhatt, Maala, Milwid, Rachael, Champredon, David, Turgeon, Patricia, Zemek, Roger, Dawson, Lauren, Mitsakakis, Nicholas, Webster, Richard, Caulley, Lisa, Angel, Jonathan B., Bastien, Nathalie, Poliquin, Guillaume, Johnson-Obaseki, Stephanie
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Zdroj: CMAJ Open; 2022, Vol. 10 Issue 4, pE981-E987, 7p
Abstrakt: Background: Accurate and timely testing for SARS-CoV-2 in the pediatric population is crucial to control the COVID-19 pandemic; saliva testing has been proposed as a less invasive alternative to nasopharyngeal swabs. We sought to compare the detection of SARS-CoV-2 using saliva versus nasopharyngeal swab in the pediatric population, and to determine the optimum time of testing for SARS-CoV-2 using saliva. Methods: We conducted a longitudinal diagnostic study in Ottawa, Canada, from Jan. 19 to Mar. 26, 2021. Children aged 3–17 years were eligible if they exhibited symptoms of COVID-19, had been identified as a high-risk or close contact to someone confirmed positive for SARS-CoV-2 or had travelled outside Canada in the previous 14 days. Participants provided both nasopharyngeal swab and saliva samples. Saliva was collected using a self-collection kit (DNA Genotek, OM-505) or a sponge-based kit (DNA Genotek, ORE-100) if they could not provide a saliva sample into a tube. Results: Among 1580 paired nasopharyngeal and saliva tests, 60 paired samples were positive for SARS-CoV-2. Forty-four (73.3%) were concordant-positive results and 16 (26.6%) were discordant, among which 8 were positive only on nasopharyngeal swab and 8 were positive only on saliva testing. The sensitivity of saliva was 84.6% (95% confidence interval 71.9%–93.1%). Interpretation: Salivary testing for SARS-CoV-2 in the pediatric population is less invasive and shows similar detection of SARS-CoV-2 to nasopharyngeal swabs. It may therefore provide a feasible alternative for diagnosis of SARS-CoV-2 infection in children. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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