| Autor: |
de Giorgi, Luisa, Matossian-Rogers, Apri, Festensteim, Hilliard |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Feb1978, Vol. 31 Issue 2, p209-217, 9p |
| Abstrakt: |
Effector cells from mice of the C57BI/10 congenic series, alloimmunized against K end- or D end-identical I region incompatible lymphocytes, were cytostatic for tumour and macrophage targets bearing syngeneic K-end anti D-end antigens. If incompatibility during immunization was restricted to the I-B subregion only, cytostasis was directed against K end syngeneic antigens; further incompatibility in the I region was required to obtain cytostasis against D-end self-antigens. Cytostasis against self-antigens was also obtained after immunization with syngeneic tumour cells; in one instance this was directed against syngeneic K-end antigens only. The implications of these findings in relation to neoplastic change and autoimmune damage are discussed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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