| Autor: |
K. V., Karapetyan, K. A., Nebogova, O. H., Nazaryan, V. P., Khacbatryan, M. H., Danielyan |
| Předmět: |
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| Zdroj: |
Ajastan Kensabanakan Handes; 2020 Supplement, Vol. 72, p21-22, 2p |
| Abstrakt: |
Parkinson's disease is the most common movement disorder in a wide range of neurodegenerative diseases, primarily resulting from the death of the dopaminergic neurons of the substantia nigra and associated with the gradual degradation of the individual. Therapy aimed at slowing down the death of dopaminergic neurons can be effective. A comparative study of the morphofunctional state of the cellular structures of rats substantia nigra neurons of the Parkinson's disease rotenone model and also on this model with treatment by venom of the Central Asian cobra Naja naja oxiana (NOX) and with the introduction of galannine has been carried out. Analysis of the results of the study shows that with the introduction of galarmine and small doses of venom, an increase in phosphatase activity is observed, the normal morphological picture is preserved, positive changes in the structural properties of the substantia nigra neurons are compared with the Parkinson's disease model, and galarmin is more effective. The data obtained suggest that galarmine and small doses of NOX venom act as a neuroprotective agents. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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