Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo.

Autor: Judák, Linda, Chiovini, Balázs, Juhász, Gábor, Pálfi, Dénes, Mezriczky, Zsolt, Szadai, Zoltán, Katona, Gergely, Szmola, Benedek, Ócsai, Katalin, Martinecz, Bernadett, Mihály, Anna, Dénes, Ádám, Kerekes, Bálint, Szepesi, Áron, Szalay, Gergely, Ulbert, István, Mucsi, Zoltán, Roska, Botond, Rózsa, Balázs
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Zdroj: Nature Communications; 11/8/2022, Vol. 13 Issue 1, p1-15, 15p
Abstrakt: Neuronal plasticity has been shown to be causally linked to coincidence detection through dendritic spikes (dSpikes). We demonstrate the existence of SPW-R-associated, branch-specific, local dSpikes and their computational role in basal dendrites of hippocampal PV+ interneurons in awake animals. To measure the entire dendritic arbor of long thin dendrites during SPW-Rs, we used fast 3D acousto-optical imaging through an eccentric deep-brain adapter and ipsilateral local field potential recording. The regenerative calcium spike started at variable, NMDA-AMPA-dependent, hot spots and propagated in both direction with a high amplitude beyond a critical distance threshold (~150 µm) involving voltage-gated calcium channels. A supralinear dendritic summation emerged during SPW-R doublets when two successive SPW-R events coincide within a short temporal window (~150 ms), e.g., during more complex association tasks, and generated large dSpikes with an about 2.5-3-fold amplitude increase which propagated down to the soma. Our results suggest that these doublet-associated dSpikes can work as a dendritic-level temporal and spatial coincidence detector during SPW-R-related network computation in awake mice. The influence of sharp-wave ripples (SPW-Rs) on dendritic computation remains poorly understood. Here, the authors demonstrate the existence of SPW-R associated, branch-specific, dendritic spikes which serve as a temporal and spatial coincidence detectors during SPW-R-doublets in PV+ interneuron dendrites of awake mice. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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