Local endovascular delivery, gene therapy, and cell transplantation for peripheral arterial disease.

Autor:	Opie, Shaun R, Dib, Nabil
Předmět:	STEM cell transplantation ARTERIOSCLEROSIS treatment PERIPHERAL vascular disease treatment ARTERIAL occlusions GENETICS COLLATERAL circulation STENOSIS NEOVASCULARIZATION GROWTH factors SURGICAL stents DISEASE relapse GENE therapy CATHETERIZATION VASCULAR endothelial growth factors ANIMALS
Zdroj:	Journal of Endovascular Therapy; Dec2004 Supplement 2, Vol. 11, pII151-II162, 12p
Abstrakt:	Advances in catheter technology, gene identification, and cell biology may provide novel treatment options for patients with peripheral arterial disease (PAD) who are not candidates for standard revascularization procedures. Animal studies and recent results in human beings suggest that transfer of growth factors or regulatory genes and transplantation of progenitor cells may provide novel therapy options by inducing therapeutic angiogenesis or by inhibiting restenosis. This review will discuss the development of a variety of catheters for localized endovascular delivery, as well as the various cellular and genetic strategies that exist to restore blood flow to ischemic tissue and to reduce neointimal hyperplasia. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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