Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease.

Autor: O'Connell, Timothy D., Murphy, Katherine A., Naixin Zhang, Puccini, Sara J., Healy, Chastity L., Harsch, Brian A., Zhang, Michael J., Shearer, Gregory C.
Předmět:
Zdroj: Physiology; Nov2022, Vol. 37 Issue 6, p311-322, 12p
Abstrakt: A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index