| Autor: |
Casini, Alessandro, Pizzigallo, Anna Maria, Mari, Francesco, Bertol, Elisabetta, Surrenti, Calogero |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); May1994, Vol. 89 Issue 5, p745-749, 5p, 3 Graphs |
| Abstrakt: |
Objective: To verify whether a prolonged (therapeutic) treatment with ranitidine or famotidine may affect blood alcohol concentrations (BAC) in patients with duodenal ulcer (DU). Methods: Sixteen male patients with DU were studied. Subjects with Helicobacter pylori-associated DU did not enter the study. Patients randomly received either 300 mg ranitidine (n = 8) or 40 mg famotidine (n = 8) at bedtime for 2 months. They had a standard lunch (1:00 PM), and 0.3 g/kg of alcohol was given 15 min after the meal. BAC were measured by head-space gas chromatography up to 150 min. Results: The rate of GFPM was checked in all patients before they entered the study; we found it to be 53%, by comparing the area under the curve (AUC) of BAC after either intravenous or oral (po) administration of 0.3 g/kg ethanol. Ranitidine did not significantly modify either the mean AUCpo (5.8 ± 1.8 vs. 6.2 ± 1.4 mM/ h, before vs. after treatment) or the peak BAC (4.6 ± 1.1 vs. 5.3 ± 1.7 mM) after 2 months of treatment. Famotidine failed to affect BAC in the second group of patients (AUCpo 5.0 ± 1.4 vs. 5.6 ± 1.7 mM/h, peak BAC 4.0 ± 1.7 vs. 4.3 ± 1.8 mM; before vs. after treatment). Conclusions: These findings suggest that, in males with DU, prolonged treatment with ranitidine or famotidine had no effect on BAC after administration of a small dose of postprandial alcohol. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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