The Cumulative Effect of Antipsychotic Usage on Mortality in Schizophrenia: A Nationwide Population-based Cohort Study in Korea.

Autor: Gyurin Kim, Soo Jung Rim, Minkyung Jo, Min Geu Lee, Se Jin Park, Subin Park
Předmět:
Zdroj: Clinical Psychopharmacology & Neuroscience; Aug2022, Vol. 20 Issue 3, p573-577, 5p
Abstrakt: Objective: To investigate the cumulative effect of antipsychotics at different dosages on mortality in patients with schizophrenia. Methods: We analyzed data from the Korean National Health Insurance System-National Sample Cohort covering the 2002-2013 period. We used Cox regression analysis to calculate hazard ratios for mortality risks according to cumulative antipsychotic exposure levels (low, moderate, and high). Results: Our analyses revealed no significant association between antipsychotic exposure and mortality (either all-cause or cause-specific) in patients with schizophrenia. Conclusion: Our results imply that the excess mortality of patients with schizophrenia is attributable to factors other than antipsychotic usage. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index