| Autor: |
Gurram, Sandeep, Agrawal, Aakash, Bhattacharya, Amitabh, Kamble, Nitish, Yadav, Ravi, Pal, Pramod K. |
| Předmět: |
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| Zdroj: |
Annals of Movement Disorders; 2022 Supplement, Vol. 5, pS21-S22, 2p |
| Abstrakt: |
Aim and Objective: To study the pattern of cortical excitability and inhibition in vascular parkinsonism (VP). Materials and Methods: Our study included 20 patients of VP (five women) and 22 healthy controls (HC; five women). All the subjects underwent Transcranial Magnetic Stimulation (TMS) with recording of resting motor threshold (RMT), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), and silent period (SP) in the contralateral upper limb. Besides, RMT and CMCT were also recorded in the contralateral lower limb. Cognitive assessments were done using Montreal cognitive assessment (MoCA) and Addenbrooke's cognitive evaluation III (ACE III). Results: The mean age of the patients (63.90 ± 7.36 years) was comparable with that of controls (59.77 ± 6.94 years) (P = 0.07). The duration of disease was 2.58 ± 2.57 years. The upper and lower limb RMT of patients (32.45 ± 4.81% and 57.20 ± 11.54%, respectively) was significantly low compared to HC (43.64 ± 7.73% and 69.18 ± 14.27%, respectively) (P < 0.001). The lower limb CMCT was prolonged in patients with VP. In addition, there was a significant reduction in SICI in patients (1.87 ± 2.03) compared to HC (0.38 ± 0.29) (P < 0.001). There was a positive correlation of SICI with MoCA (r = 0.45, P < 0.05) and ACE-III (r = 0.33, P < 0.05) scores. Conclusion: The reduction in RMT and SICI in patients with VP suggests abnormalities in GABAergic and other monoamine neurotransmission in these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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