| Autor: |
Siripurapu, Govinda, Verma, Bhawna, Biswas, Deblina, Vishnoi, Aayushi, Agarwal, Ayush, M. R., Divya, A., Elavarasi, Gupta, Anu, V. Y., Vishnu, Singh, Mamta B., Bhatia, Rohit, Tripathi, Manjari, Srivastava, Achal, Srivastava, M. V. Padma, Rajan, Roopa |
| Předmět: |
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| Zdroj: |
Annals of Movement Disorders; 2022 Supplement, Vol. 5, pS5-S6, 2p |
| Abstrakt: |
Objective: To assess deficits in social cognition among patients with Parkinson's disease (PD). Background: Social cognition is the study of how people make sense of themselves and others. Deficits in social cognition may affect interpersonal relationships and social functions. PD is a complex neurodegenerative disease with multiple motor and nonmotor symptoms. Cognitive problems are dominant in advanced PD, and subtle impairment in various cognitive domains may coexist even in early PD. There are four subdomains of social cognition: emotion processing, theory of mind (ToM), social perception and knowledge, and attributional bias. In this study, we explored for the first time, all domains of social cognition in Indian PD patients using a culturally appropriate, validated instrument. Methods: We conducted a cross-sectional study including 52 patients with PD and 31 age, gendermatched healthy controls (HCs) [Figure 1]. We used Hamilton Depression Rating Scale (HAM-D) and Montreal Cognitive Assessment (MOCA) scores to exclude patients with significant depression and cognitive impairment. We applied the SOCRATIS (Social Cognition Rating Tools in Indian Setting) tool to score the ToM, attributional biases, and social cue perception [Figure 2]. Additionally, we assessed the quality of life (QOL) in PD using the Parkinson's Disease Quality of Life scale. Results: Baseline characteristics were comparable between PD and HC. There were statistically significant deficits in three indices of social cognition in PD patients compared to HCs. The mean (SD) of FOT index (first-order ToM index) in PD was 0.86 ± 0.18 and HC was 0.99 ± 0.07 [P < 0.001]. There was higher externalizing bias (EB) in the PD group (4.42 ± 3.91), compared to the control group (1.58 ± 3.22) [P = 0.001]. The mean (SD) of FPCI ALT (Faux Pas Composite Index) in PD was 0.69 ± 0.09 compared to HC (0.78 ± 0.13) (P < 0.001). Social cognition indices were not associated with QOL in PD [Table 1]. Clinical parameters age, gender, HAM-D, MOCA, education, levodopa equivalent daily dose of medication, number of PD drugs, and trihexyphenidyl use were not predictors of social cognition. Conclusion: In this study, PD patients were less successful than age, gender-matched controls in understanding social situations and other's thought processes and had a higher tendency to attribute undesirable events to external causes. Deficits in social cognition did not impair the QOL. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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